Scientific literature cited:
Journal of Cancer, volume 4, pages 703-715, November 2013:
Title of Article: Simultaneous Inhibition of Cell-Cycle, Proliferation, Survival, Metastatic Pathways and Induction of Apoptosis in Breast Cancer Cells by a Phytochemical Super-Cocktail: Genes That Underpin Its Mode of Action
Abstract
Traditional chemotherapy and radiotherapy for cancer treatment face serious challenges such as drug resistance and toxic side effects. Complementary / Alternative medicine is increasingly being practiced worldwide due to its safety beneficial therapeutic effects. We hypothesized that a super
combination (SC) of known phytochemicals used at bioavailable levels could induce 100% killing of breast cancer (BC) cells without toxic effects on normal cells and that microarray analysis would identify potential genes for targeted therapy of BC. Mesenchymal Stems cells (MSC, control) and two BC cell lines were treated with six well established pro-apoptotic phytochemicals individually and in combination (super cocktail), at bioavailable levels. The compounds were ineffective individually. In combination, they significantly suppressed BC cell proliferation (>80%), inhibited migration and invasion, caused cell cycle arrest and induced apoptosis resulting in 100% cell death. However, there were no deleterious effects on MSC cells used as control. Furthermore, the SC down-regulated the expression of PCNA, Rb, CDK4, BcL-2, SVV, and CD44 (metastasis inducing stem cell factor) in the BC cell lines. Microarray analysis revealed several differentially expressed key genes (PCNA, Rb, CDK4, Bcl-2, SVV, P53 and CD44) underpinning SC-promoted BC cell death and motility. Four unique genes were highly up-regulated (ARC, GADD45B, MYLIP and CDKN1C). This investigation indicates the potential for development of a highly effective phytochemical combination for breast cancer chemoprevention / chemotherapy. The novel over-expressed genes hold the potential for development as markers to follow efficacy of therapy.
Letter from a Patron who has been using Breast Safeguard Susthana for several years:
Dear Dr. Raj,
For at least 7 years, I have been faithfully taking Breastsafeguard twice daily and truly believe it has helped maintain my health post breast cancer diagnosis in 2016. For 2 miserable years, I took Arimidex, an estrogen blocker, as suggested by my oncologist. There were numerous side effects and my quality of life was severely impacted. Shortly after discontinuing the medication, I was introduced to Breastsafeguard.
This super cocktail contains so many antioxidants and nutritious benefits! I could not possibly consume the amount of fruits and vegetables in a day that I can get with this magnificent supplement. It seems like I am having increasing trouble taking prescription medication as well as some OTC supplements in recent years. However, I have never had any untoward side effects from taking Breastsafeguard Susthana.
There is no doubt in my mind that Breastsafeguard has significantly contributed to my overall health over the past several years. I feel so blessed to have this information and hope that others would discover the benefits of this amazing supplement.
Thank you again, Dr. Raj, for your interest in wellness and your perseverance to provide quality products. You are such an inspiration and want you to know how much I appreciate you!
Jane Fandrich